Stochasticity in Action Potential duration Enhances Dispersion of Repolarisation at Fast Pacing Rates
نویسندگان
چکیده
منابع مشابه
Cellular uncoupling can unmask dispersion of action potential duration in ventricular myocardium. A computer modeling study.
Although slow conduction is a requirement for the preparation of sustained reentry, it alone is not sufficient for the initiation of reentry. Additionally, unidirectional block and recovery of excitability distal to the site of block must occur. Thus, a comprehensive description of the electrophysiological determinants of reentry must explain both slow conduction and unidirectional block. Altho...
متن کاملAction potential duration dispersion and alternans in simulated heterogeneous cardiac tissue with a structural barrier.
Structural barriers to wave propagation in cardiac tissue are associated with a decreased threshold for repolarization alternans both experimentally and clinically. Using computer simulations, we investigated the effects of a structural barrier on the onset of spatially concordant and discordant alternans. We used two-dimensional tissue geometry with heterogeneity in selected potassium conducta...
متن کاملDispersion of cardiac action potential duration and the initiation of re-entry: A computational study
BACKGROUND The initiation of re-entrant cardiac arrhythmias is associated with increased dispersion of repolarisation, but the details are difficult to investigate either experimentally or clinically. We used a computational model of cardiac tissue to study systematically the association between action potential duration (APD) dispersion and susceptibility to re-entry. METHODS We simulated a ...
متن کاملDispersion of cardiac action potential duration and the initiation of re - entry : A computational study Richard
Background: The initiation of re-entrant cardiac arrhythmias is associated with increased dispersion of repolarisation, but the details are difficult to investigate either experimentally or clinically. We used a computational model of cardiac tissue to study systematically the association between action potential duration (APD) dispersion and susceptibility to re-entry. Methods: We simulated a ...
متن کاملElectrotonic influences on action potential duration dispersion in small hearts: a simulation study.
Intrinsic spatial variations in repolarization currents in the heart can produce spatial gradients in action potential duration (APD) that serve as possible sites for conduction block and the initiation of reentrant activity. In well-coupled myocardium, however, electrotonic influences at the stimulus site and wavefront collision sites act to modulate any intrinsic heterogeneity in APD. These e...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2012
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2011.11.3230